The Siu group uses mass spectrometry to perform research in the bioanalytical and biophysical areas. There are three major research thrusts:
Fundamentals in Mass Spectrometry: formation and dissociation chemistries of peptide radical ions; structure and energetics of divalent and trivalent metal-containing peptide complexes, and their dissociations; metal-ligand binding energies. Most studies have an experimental as well as a computational component, the latter is conducted in collaboration with Professor Alan C. Hopkinson. Next-Generation Mass-Spectrometric Hardware Development: ion-mobility measurements in high-pressure, segmented quadrupoles; infrared multiphoton dissociation and ultraviolet photodissociation in hybrid QqTOF tandem mass spectrometry; ion/ion reactions in linear quadrupole instrumentation; ring ion guide. Most studies are conducted in collaboration with Drs. Bruce A. Thomson and J.C. Yves Le Blanc of MDS Analytical Technologies. -
Proteomics and Cancer Biomarker Discovery and Quantification: shot-gun organellar proteomics of Tetrahymena thermophila; myogenesis-related proteins and their posttranslational modifications; endometrial, brain, head-and-neck, ovarian, and kidney cancer biomarker discovery, identification, verification, and quantification. Collaborators include, Professors Ronald E. Pearlman and John C. McDermott (York University); Drs. Terence J. Colgan, Christina M. MacMillan, Ian J. Witterick, and Iona Leong (Mount Sinai Hospital); Drs. Alexander D. Romaschin and George M. Yousef (St. Michael’s Hospital); Dr. Abhijit Guha (Hospital for Sick Children and Toronto Western Hospital); Professor Ranju Ralhan (Mount Sinai Hospital and Visiting Professor, York University); and Drs. Kenneth R. Evans and Terrence Sills (Ontario Cancer Biomarker Network).
See details of recent studies in the hyperlinked PDF files of publications in the listed years. |
